Thomas J. Silhavy

Thomas J. Silhavy
Thomas J. Silhavy
Born	1948
Died	-
Nationality	American
Fields	molecular biology
Institutions	Princeton University
Notable awards	Novitski Prize, in 2008

Thomas J. Silhavy is the Warner-Lambert Parke-Davis Professor of molecular biology at Princeton University. Silhavy is a bacterial geneticist who has made fundamental contributions to several different research fields. He is best known for his work on protein secretion, membrane biogenesis, and signal transduction. Using Escherichia coli as a model system, his lab was the first to isolate signal sequence mutations, to identify a component of cellular protein secretion machinery, and an integral membrane component of the outer membrane assembly machinery, and to identify and characterize a two-component regulatory system.^[1] Current work in his lab is focused on the mechanisms of outer membrane biogenesis and the regulatory systems that sense and respond to envelope stress and trigger the developmental pathway that allows cells to survive starvation. He is the author of more than 200 research articles and three books.

Silhavy was elected to the National Academy of Sciences in 2005.^[2]

Contents 1 Honors 2 Selected Publications 3 External links 4 References

Honors

• 2008 Novitski Prize ^[3]

• 2008 Associate Member of the European Molecular Biology Organization (EMBO) ^[4]

• 2005 Member of American Academy of Arts and Sciences ^[5]

• 2002 Graduate Microbiology Teaching Award from American Society for Microbiology ^[6]

Selected Publications

• Button JE, Silhavy TJ, Ruiz N (2006). "A suppressor of cell death caused by the loss of {sigma}E downregulates extracytoplasmic stress responses and outer membrane vesicle production in Escherichia coli" Journal of Bacteriology [Epub ahead of print]

• Ruiz N, Wu T, Kahne D, Silhavy TJ (2006). "Probing the barrier function of the outer membrane with chemical conditionality" ACS Chemistry and Biology 1: 385-395.

• Ureta AR, Endres RG, Wingreen NS, Silhavy TJ (2006). "Kinetic analysis of the assembly of the outer membrane protein LamB in Escherichia coli mutants each lacking a secretion or targeting factor in a different cellular compartment" Journal of Bacteriology 189: 446-454.

• Gaal T, Mandel MJ, Silhavy TJ, Gourse RL (2006). "Crl facilitates RNA polymerase holoenzyme formation" Journal of Bacteriology 188: 7966-7970.

• Malinverni JC, Werner J, Kim S, Sklar JG, Kahne D, Misra R, Silhavy TJ (2006). "YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli" Molecular Microbiology 61: 151-164.

• Peterson CN, Carabetta VJ, Chowdhury T, Silhavy TJ (2006). "LrhA regulates rpoS translation in response to the Rcs phosphorelay system in Escherichia coli" Journal of Bacteriology 188: 3175-3181.

• Ruiz N, Kahne D, Silhavy TJ (2006). "Advances in understanding bacterial outer-membrane biogenesis" Nature reviews: Microbiology 4: 57-66.

• Isaac DD, Pinkner JS, Hultgren SJ, Silhavy TJ (2006). "The extracytoplasmic adaptor protein CpxP is degraded with substrate by DegP" Proceedings of the National Academy of Sciences (USA) 102: 17775-17779.

• Justice SS, Hunstad DA, Harper JR, Duguay AR, Pinkner JS, Bann J, Frieden C, Silhavy TJ, Hultgren SJ (2005). "Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli" Journal of Bacteriology 187: 7680-7686.

• Peterson CN, Mandel MJ, Silhavy TJ (2005). "Escherichia coli starvation diets: essential nutrients weigh in distinctly" Journal of Bacteriology 187: 7549-7553.

• Ruiz N, Falcone B, Kahne D and Silhavy TJ (2005). "Chemical conditionality: a genetic strategy to probe organelle assembly" Cell 121: 307-317.

• Wu T, Malinverni J, Ruiz N, Kim S, Silhavy TJ and Kahne D (2005). "Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli" Cell 121: 235-245.

• Ruiz N, Silhavy TJ (2005). "Sensing external stress: watchdogs of the Escherichia coli cell envelope" Current Opinion in Microbiology 8: 122-126.

• Mandel MJ and Silhavy TJ (2005). "Starvation for different nutrients in Escherichia coli results in differential modulation of RpoS levels and stability" Journal of Bacteriology 187: 434-442.

• Duguay AR, Silhavy TJ (2004). "Quality control in the bacterial periplasm" Biochimica et Biophysica Acta 1694: 121-134.

• Batchelor E, Silhavy TJ, Goulian M (2004). "Continuous control in bacterial regulatory circuits" Journal of Bacteriology 186: 7618-7625.

• Peterson CN, Ruiz N and Silhavy TJ (2004). "RpoS proteolysis is regulated by a mechanism that does not require the SprE (RssB) response regulator phosphorylation site" Journal of Bacteriology 186: 7403-7410.

• Gibbs KA, Isaac DD, Xu J, Hendrix RW, Silhavy TJ, Theriot JA (2004). "Complex spatial distribution and dynamics of an abundant Escherichia coli outer membrane protein, LamB" Molecular Microbiology 53: 1771-1783.

• Lee YM, DiGiuseppe PA, Silhavy TJ, Hultgren SJ (2004). "P pilus assembly motif necessary for activation of the CpxRA pathway by PapE in Escherichia coli" Journal of Bacteriology 186: 4326-4337.

• Hand NJ and Silhavy TJ (2004). "Null mutations in a Nudix gene, ygdP, implicate an alarmone response in a novel suppression of hybrid jamming" Journal of Bacteriology 185: 6530-6539.

• Ruiz N and Silhavy TJ (2003). "Constitutive activation of the Escherichia coli Pho regulon upregulates rpoS translation in an Hfq-dependent fashion" Journal of Bacteriology 185: 5984-5992.

• Bowers CW, Lau F and Silhavy TJ (2003). "Secretion of LamB-LacZ by the signal recognition particle pathway of Escherichia coli" Journal of Bacteriology 185: 5697-5705.

• Shuman HA and Silhavy TJ (2003). "The art and design of genetic screens: Escherichia coli" Nature reviews: Genetics 4: 419-431.

• DiGiuseppe PA and Silhavy TJ (2003). "Signal detection and target gene induction by the CpxRA two-component system" Journal of Bacteriology 185: 2432-2440.

• Duguay AR, Silhavy TJ (2002). "Signal sequence mutations as tools for the characterization of LamB folding intermediates" Journal of Bacteriology 184: 6918-6928.

• Braun M and Silhavy TJ (2002). "Imp/OstA is required for cell envelope biogenesis in Escherichia coli" Molecular Microbiology 45: 1289-1302.

• Otto K and Silhavy TJ (2002). "Surface sensing and adhesion of Escherichia coli controlled by the Cpx-signaling pathway" Proceedings of the National Academy of Sciences (USA) 99: 2287-2292.

External links

• Profile of Silhavy

References

1. ^ http://www.nasonline.org/site/Dir/1945751719?pg=vprof&mbr=1006677&returl=http%3A%2F%2Fwww.nasonline.org%2Fsite%2FDir%2F1945751719%3Fpg%3Dsrch%26view%3Dbasic&retmk=search_again_link retrieved 2010-08-12
2. ^ http://www.pnas.org/content/102/21/7405/suppl/DC1 retrieved 2010-08-12
3. ^ *Thorner, Jeremy W (March 2008). "The 2008 Novitski Prize". Genetics 178 (3): 1135–6. doi:10.1534/genetics.104.017831. PMC 2278103. PMID 18385107. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2278103.  retrieved 2010-08-12
4. ^ http://www.embo.org/news/press-release-2008/new-embo-members-2008.html retrieved 2010-08-12
5. ^ http://www.amacad.org/news/new2005.aspx retrieved 2010-08-12
6. ^ http://asm.org/asm/index.php/professional-development/asm-graduate-microbiology-teaching-award-past-laureates.html retrieved 2010-08-16

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Name	Silhavy, Thomas
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Date of birth	1948
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